{"id":8,"date":"2018-06-08T10:44:19","date_gmt":"2018-06-08T10:44:19","guid":{"rendered":"https:\/\/orgchem.lums.edu.pk\/?page_id=8"},"modified":"2026-10-27T17:44:39","modified_gmt":"2026-10-27T12:44:39","slug":"publications","status":"publish","type":"page","link":"https:\/\/orgchem.lums.edu.pk\/index.php\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
\n

Selected Publications<\/h2>\n

Selected papers by topic. For the complete, up-to-date list, see Google Scholar<\/a>.<\/p>\n

* corresponding author<\/p>\n\n

Anticancer drug discovery<\/summary>
    \n
  1. Firdous F, Farrukh SUB, Furqan M, et al., Myant KB, et al., Saleem RSZ<\/strong>*, Faisal A*. Novel 1,2,5-selenadiazole derivatives as microtubule-targeting agents that overcome multidrug resistance. Arch. Pharm.<\/em> 2025, 358, e70087. doi<\/a><\/li>\n
  2. Muddassar M, Furqan M, et al., Saleem RSZ<\/strong>, et al., Faisal A*. Computational identification and experimental characterization of an Aurora kinase inhibitor. Bioorg. Med. Chem.<\/em> 2025, 123, 118160. doi<\/a><\/li>\n
  3. Iqbal S, Firdous F, Furqan M, et al., Myant KB, et al., Faisal A*, Saleem RSZ<\/strong>*. Bis-amide SSE1917 as a microtubule-stabilizing anticancer agent. Bioorg. Chem.<\/em> 2024, 143, 107094. doi<\/a><\/li>\n
  4. Saleem RSZ<\/strong>, Schwalm MP, Knapp S. Expanding the ligand spaces for E3 ligases for the design of protein degraders. Bioorg. Med. Chem.<\/em> 2024, 105, 117718. doi<\/a><\/li>\n
  5. Firdous F, Riaz S, Furqan M, et al., Myant KB, et al., Saleem RSZ<\/strong>*, Faisal A*. 4-Azapodophyllotoxin derivatives as microtubule-targeting agents that can overcome multidrug resistance. ACS Med. Chem. Lett.<\/em> 2023, 14, 1369. doi<\/a><\/li>\n
  6. Firdous F, Ibrahim R, Furqan M, et al., Faisal A*, Saleem RSZ<\/strong>*. Griseofulvin derivatives as microtubule-stabilizing agents. ChemistrySelect<\/em> 2022, 7, e202202832. doi<\/a><\/li>\n
  7. Furqan M, Fayyaz A, Firdous F, et al., Saleem RSZ<\/strong>, et al., Faisal A*. Quinones as Aurora kinase inhibitors. J. Nat. Prod.<\/em> 2022, 85, 1503. doi<\/a><\/li>\n
  8. Farrukh SUB, Bilal A, Zahid H, et al., Saleem RSZ<\/strong>*, Faisal A*. Novel carboxamides causing centrosome declustering and apoptosis in breast cancer cells. ChemistrySelect<\/em> 2022, 7, e202104218. doi<\/a><\/li>\n
  9. Tariq MU, Parveen H, Furqan M, et al., Saleem RSZ<\/strong>, et al., Faisal A*. CCT245718, a dual FLT3\/Aurora A inhibitor, overcomes D835Y-mediated resistance to FLT3 inhibitors in AML cells. Br. J. Cancer<\/em> 2021, 125, 966. doi<\/a> (2021 Bashir-Alavi Award)<\/li>\n
  10. Malik HS, Bilal A, Ullah R, et al., Saleem RSZ<\/strong>, Hussain H*, Faisal A*. Natural and semisynthetic chalcones as dual FLT3 and microtubule polymerization inhibitors. J. Nat. Prod.<\/em> 2020, 83, 3111. doi<\/a><\/li>\n
  11. Riaz S, Iqbal M, Ullah R, et al., Faisal A*, Saleem RSZ<\/strong>*. Novel \u03b1-substituted chalcones with potent anticancer activity and ability to overcome multidrug resistance. Bioorg. Chem.<\/em> 2019, 87, 123. doi<\/a><\/li>\n
  12. Manzoor S, Bilal A, Khan S, et al., Saleem RSZ<\/strong>*, Faisal A*. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci. Rep.<\/em> 2018, 8, 3305. doi<\/a><\/li>\n
  13. Iftikhar S, Khan S, Bilal A, et al., Faisal A*, Saleem RSZ<\/strong>*. Modified chalcone-based p53 stabilizing agents. Bioorg. Med. Chem. Lett.<\/em> 2017, 27, 4101. doi<\/a><\/li>\n
  14. Nguyen TNT, Saleem RSZ<\/strong>, et al., Tepe JJ*. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chem. Biol.<\/em> 2012, 7, 172. doi<\/a><\/li>\n
  15. Saleem RSZ<\/strong>, Lansdell TA, Tepe JJ*. Debromohymenialdisine-derived Chk2 inhibitors. Bioorg. Med. Chem.<\/em> 2012, 20, 1475. doi<\/a><\/li>\n<\/ol>\n<\/details>\n
    Antiviral and anti-infective drug discovery and open science<\/summary>
      \n
    1. Isaksson R, Carter E, Hind C, et al., Saleem RSZ<\/strong>, et al., Todd MH*. Idler compounds: a simple protocol for openly sharing fridge contents for cross-screening. J. Med. Chem.<\/em> 2026, 69, 2453. doi<\/a> (ACS Editors\u2019 Choice)<\/li>\n
    2. Oh H, Sears J, Ramalingam MB, Saleem RSZ<\/strong>, et al. Spirodioxolane nsP2 helicase inhibitors with antialphaviral activity. RSC Med. Chem.<\/em> 2026, 17, 452. doi<\/a><\/li>\n
    3. Duong HP, Melechov D, Lim W, Jingyi M, et al., Saleem RSZ<\/strong>, et al., Todd MH*. Fenarimol analogues active against Madurella mycetomatis<\/em>, the main causative agent of eumycetoma. RSC Med. Chem.<\/em> 2025, 16, 6094. doi<\/a><\/li>\n<\/ol>\n<\/details>\n
      Inhibitors of amyloid aggregation<\/summary>
        \n
      1. Kalsoom U, Alazmi M, Farrukh SUB, et al., Javed I*, Davis TP*, Saleem RSZ<\/strong>*. Differential modulation of A\u03b2 fibrillization by selenadiazole-based inhibitors. ACS Chem. Neurosci.<\/em> 2021, 12, 3806. doi<\/a><\/li>\n
      2. Farrukh SUB, Javed I, Ather AQ, et al., Saleem RSZ<\/strong>*. Pyridazinylpyrazolone-based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation. Bioorg. Chem.<\/em> 2019, 84, 339. doi<\/a><\/li>\n<\/ol>\n<\/details>\n
        Organoselenium chemistry<\/summary>
          \n
        1. Friberg LIM, Kavanagh A, et al., Saleem RSZ<\/strong>, et al., Blaskovich MAT*, Hansford KA*. Organoselenium compounds as an enriched source for the discovery of new antimicrobial agents. RSC Med. Chem.<\/em> 2025, 16, 3213. doi<\/a><\/li>\n
        2. Nasim MJ*, Ali W, da Silva J\u00fanior EN, Saleem RSZ<\/strong>, et al., Jacob C*. The chalcogen exchange. Sci<\/em> 2025, 7, 74. doi<\/a><\/li>\n
        3. Nawaz I, Khan MN, Shah S, Hawsawi M, Saleem RSZ<\/strong>*, Chotana G*. NHC-derived amide-functionalized organoselenium compounds. ACS Omega<\/em> 2025, 10, 10579. doi<\/a><\/li>\n
        4. Alhasan R, Martins GM, De Castro PP, Saleem RSZ<\/strong>, et al., Jacob C. Selenoneine-derived selenohydantoin with glutathione peroxidase-like activity. Bioorg. Med. Chem.<\/em> 2023, 94, 117479. doi<\/a><\/li>\n
        5. Rendekov\u00e1 J, et al., Saleem RSZ<\/strong>, et al., Jacob C*. The selenium\u2013nitrogen bond as basis for reactive selenium species with antimicrobial activity. Curr. Org. Synth.<\/em> 2017, 14, 1082. doi<\/a><\/li>\n<\/ol>\n<\/details>\n
          Natural products, total synthesis and methodology<\/summary>
            \n
          1. Nawaz I, Nawaz M, Saleem RSZ<\/strong>, Chotana GA*. SuFEx via glass-assisted organocatalysis. Adv. Synth. Catal.<\/em> 2025, 367, e202401175. doi<\/a><\/li>\n
          2. Hanif A, Sardar A, Alazmi M, et al., Saleem RSZ<\/strong>*. One-pot three-component access to arylidene 2-aminoimidazolones. ChemistrySelect<\/em> 2019, 4, 1753. doi<\/a><\/li>\n
          3. Saleem RSZ<\/strong>, Tepe JJ*. A concise total synthesis of hymenialdisine. Tetrahedron Lett.<\/em> 2015, 56, 3011. doi<\/a><\/li>\n
          4. Mehnaz S, Saleem RSZ<\/strong>, Yameen B, et al., Gross H*. Lahorenoic acids A\u2013C from the biocontrol strain Pseudomonas aurantiaca<\/em> PB-St2. J. Nat. Prod.<\/em> 2013, 76, 135. doi<\/a><\/li>\n
          5. Saleem RSZ<\/strong>, Tepe JJ*. Synthesis of 1,2,4-triazolines and triazoles utilizing oxazolones. J. Org. Chem.<\/em> 2010, 75, 4330. doi<\/a> (highlighted in Synfacts<\/em>)<\/li>\n<\/ol>\n<\/details>\n
            Organic optoelectronic materials<\/summary>
              \n
            1. Ahmed K, Khan MN, Mulla RA, et al., Saleem RSZ<\/strong>*. Substituent-modulated quinoxaline carboxamides as wide-bandgap organic optoelectronic materials. J. Mol. Struct.<\/em> 2026, accepted. doi<\/a><\/li>\n
            2. Khan MN, Umar SM, Ahmed K, et al., Saleem RSZ<\/strong>*. Pyrazoline\u2013thiazole hybrids for organic optoelectronics. J. Photochem. Photobiol. A<\/em> 2026, 481, 117426. doi<\/a><\/li>\n
            3. Khan MN, Baig H, Hanif A, et al., Saleem RSZ<\/strong>*. Tunable 2-aminoimidazolone donor\u2013acceptor chromophores. J. Photochem. Photobiol. A<\/em> 2026, 481, 117447. doi<\/a><\/li>\n
            4. Yaqoob H, Arif N, Saleem RSZ<\/strong>, et al., Chotana GA*. CF3<\/sub>-pyridyl-substituted hetero- and homocyclic conjugated molecules. Mater. Adv.<\/em> 2026, accepted. doi<\/a><\/li>\n
            5. Yaqoob H, Nawaz M, Saleem RSZ<\/strong>, Chotana GA*. Perylene-based D-\u03c0-A-\u03c0-D molecules for optoelectronic applications. J. Photochem. Photobiol. A<\/em> 2026, 470, 116661. doi<\/a><\/li>\n
            6. Khan MN, Ahmed K, Siddiqui L, et al., Saleem RSZ<\/strong>*. Naphthyl chalcones for photovoltaic applications. J. Mol. Struct.<\/em> 2025, 142526. doi<\/a><\/li>\n
            7. Baig H, Iqbal A, Rasool A, et al., Saleem RSZ<\/strong>*. Piperidyl and pyrrolidinyl chalcones. ACS Omega<\/em> 2023, 8, 28499. doi<\/a><\/li>\n
            8. Baig H, Irfan R, Rasool A, et al., Saleem RSZ<\/strong>*. 4-Aminochalcones. J. Photochem. Photobiol. A<\/em> 2023, 114790. doi<\/a><\/li>\n
            9. Baig H, Rasool A, Hussain SZ, et al., Saleem RSZ<\/strong>*. Novel 2-aminoimidazolones. J. Photochem. Photobiol. A<\/em> 2022, 429, 113918. doi<\/a><\/li>\n<\/ol>\n<\/details>\n
              Selected reviews<\/summary>
                \n
              1. Pasha MH, Hawsawi MB, Saleem RSZ<\/strong>*. Catalytic asymmetric synthesis of hydrogenated pyridazines. J. Chem.<\/em> 2026, 5790070. doi<\/a><\/li>\n
              2. Siddiqui L, Khan KM, Saleem RSZ<\/strong>*. Recent progress in kinase-targeting antimalarial drug discovery. Mini-Rev. Med. Chem.<\/em> 2026, accepted.<\/li>\n
              3. Siddiqui L, Hawsawi M, Chotana G, Saleem RSZ<\/strong>*. Bis-chalcones in biological and materials sciences. ACS Omega<\/em> 2024, 9, 42061. doi<\/a><\/li>\n
              4. Ahmed K, Choudhary MI, Saleem RSZ<\/strong>*. Heterocyclic pyrimidine derivatives as promising antibacterial agents. Eur. J. Med. Chem.<\/em> 2023, 115701. doi<\/a><\/li>\n
              5. Firdous F, Raza HG, Chotana GA, Choudhary MI, Faisal A, Saleem RSZ<\/strong>*. Centrosome clustering and chemotherapy. Mini-Rev. Med. Chem.<\/em> 2023, 23, 429. doi<\/a><\/li>\n
              6. Ahmed K, Ashraf D, Chotana GA, Faisal A, Khan KM*, Saleem RSZ<\/strong>*. Selenium-containing peptides and their biological applications. Curr. Med. Chem.<\/em> 2022, 29, 6379. doi<\/a><\/li>\n
              7. Irfan R, Mousavi S, Alazmi M, Saleem RSZ<\/strong>*. A comprehensive review of aminochalcones. Molecules<\/em> 2020, 25, 5381. doi<\/a><\/li>\n<\/ol>\n<\/details>\n
                Book chapters<\/summary>
                  \n
                1. Darkal AK, Sarfraz M, Nasim MJ, Ney Y, Saleem RSZ<\/strong>, Jacob C. Composition, nutritional and health benefits. In Edible Alliums: Botany, Production and Uses<\/em>; CABI, 2022; pp 35\u201350.<\/li>\n
                2. Nasim MJ, Ali W, Dom\u00ednguez-\u00c1lvarez E, da Silva J\u00fanior EN, Saleem RSZ<\/strong>, Jacob C. Reactive selenium species: redox modulation, antioxidant, antimicrobial and anticancer activities. In Organoselenium Compounds in Biology and Medicine<\/em>; Royal Society of Chemistry, 2018; pp 277\u2013302. doi<\/a><\/li>\n<\/ol>\n<\/details>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

                  Selected Publications Selected papers by topic. For the complete, up-to-date list, see Google Scholar. * corresponding author Anticancer drug discovery Firdous F, Farrukh SUB, Furqan M, et al., Myant KB, et al., Saleem RSZ*, Faisal A*. Novel 1,2,5-selenadiazole derivatives as microtubule-targeting agents that overcome multidrug resistance. Arch. Pharm. 2025, 358, e70087. doi Muddassar M, Furqan […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-full-width.php","meta":{"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/orgchem.lums.edu.pk\/index.php\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/orgchem.lums.edu.pk\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/orgchem.lums.edu.pk\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/orgchem.lums.edu.pk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/orgchem.lums.edu.pk\/index.php\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":11,"href":"https:\/\/orgchem.lums.edu.pk\/index.php\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":372,"href":"https:\/\/orgchem.lums.edu.pk\/index.php\/wp-json\/wp\/v2\/pages\/8\/revisions\/372"}],"wp:attachment":[{"href":"https:\/\/orgchem.lums.edu.pk\/index.php\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}